Abstract:Abstract: Objective To investigate the clinical impact on plasma endothelin, thromboxane A2, and immune function by laparoscopic cholecystectomy (LC) in patients under general anesthesia combined with epidural anesthesia. Methods According to the order of admission, 90 cases of patients who received laparoscopic cholecystectomy in our hospital from 2013 January to 2015 January were randomly divided into single group and compound group, 45 patients in each group. Patients in single group received general anesthesia, while patients in compound group were received general anesthesia combined with epidural anesthesia. Then compare two groups of patients with hemodynamic index, thromboxane A2 (TXA2), plasma endothelin (ET), as well as immune function. Results Patients of compound group were more stable with hemodynamic indicators, such as the DBP and SBP, MAP, HR, than those in the single group, the differences between groups with statistical significance (P < 0.05 or P < 0.01). T1 TXA2 and ET was reduced of T0 in patients of both single and compound group, then time of T2~T4 TXA2 and ET increased in both groups, and TXA2 of every time and ET of time T4 raised more marked in single group than compound group, the differences between groups with statistical significance (each P < 0.01). CD3+, CD4+, CD8+ level of time T0 were significantly lower compared with of time T5 in single group (P < 0.05 or P < 0.01), while the CD4+ of compound group had no obvious change (P > 0.05), and single group had a lower level of CD3+, CD4+ on time of T7 than those in compound group, the differences between groups with statistical significance (each P < 0.01). Patients of compound group had obviously higher CD4+/CD8+ value than those in a single group on time of T5 and T7, and the differences between two groups with statistical significance (each P < 0.01). Conclusions Compared with general anesthesia, patients who receive laparoscopic cholecystectomy under general anesthesia combined with epidural anesthesia has less stress reaction, such as the patient's circulation, respiration, plasma TXA2, ET and little effect on the immune function, which can reduce the operation risk factors and accelerate the recovery of the patients with postoperative as a safe and effective anesthetic regimen.