Objective?To evaluate the effect of timing XiaoZhang acupoint application deposited on nausea and vomiting after laparoscopic myomectomy surgery (Post-Operative Nausea and Vomiting, PONV). Methods 120 cases of uterine fibroids were randomly divided into experimental group and control group. There were 5 cases in the experimental group and 4 cases in the control group have lost to follow-up, and 111 cases were included in the study. The control group (n =56) accept vomiting routine nursing and selective false acupoint application therapy intervention, the experimental group (n =55) accept vomiting routine nursing and selective XiaoZhang acupoint application therapy intervention. The incidence of nausea and vomiting in two groups were observed after operation in 0, 6, 12, 24 h respectively. Results Before intervention（postoperative 0 h), intervention (postoperative 6 h), the patients in experimental group of PONV symptoms (0~Ⅳ) compared the control group, the difference was not statistically significant (P >0.05);Intervention (postoperative 12 h and 24 h) of the patients in the experimental group PONV symptoms (0~Ⅳ) and the control group, the difference was statistically significant (P <0.05). Conclusions Selective ChenShi implementation of XiaoZhang acupoint application can effectively improve laparoscopic myomectomy surgery (0～Ⅳ) of PONV symptoms, and the side effect is slight.