Objective?To evaluate the safety and efficacy of endoscopic treatment for GSMTs compared with laparoscopic treatment.?Methods?From January 2015 to January 2012, 91 patients with GSMTs who were diagnosed and treated by endoscopy or laparoscope were retrospectively selected as study objects; 61 of them were treated by endoscope, the other 30 were treated by laparoscope. Pathological examination was taken in all removed tumors, the tumors which could be the gastic stomal tumors (GSTs) were furtherly examed with the molecular biology technique of immunohistochemistry. To analyze the gender, age, reasons for treatment of the patient, tumor location, surgical procedures, operative time, blood loss, tumor size, postoperative hospital stay, hospitalization expenses.?Results?Compared with the laparoscopic group, the endoscopic group present horteroperationtime [(55.86 ± 11.41) min compared (71.33 ± 9.90) min, t = -4.56, P < 0.01], 1ess intraoperative blood loss [(16.83 ± 4.64) ml compared (26.33 ± 4.81) ml, t = -6.40, P < 0.01], less postoperative hospital stays [(5.03 ± 2.47) d compared (7.20 ± 1.21), t = -2.17, P < 0.01], and less hospitalization expenses [(24 779.43 ± 6 202.00 compared (45 689.42 ± 10 318.47), t = -8.42, P < 0.001]. The postoperative complications rate (3.27 % compared 6.67 %, χ2 = 0.04, P > 0.05) and operation successful rate (96.7 % compared 86.67 %, χ2 = 1.87, P > 0.05) had no statistical difference. It has no tumor recurrence or distant metastasis during the follow-up time in the two groups.?Conclusions?The curative effect of endoscopic treatment for gastric submucosal tumor is similar to laparoscopy, it is safe and effective, less trauma and faster recovery, lower cost.