Objective?To elavuate the clinical value of endoscopic subcucosal dissection (ESD) in treatment of gastric stromal tumor.?Methods?This is a retrospective cohort study. From June 2012 to December 2015, 56 patients with gastric stromal tumor (diameter ≤3 cm) underwent ESD were enrolled. Clinical outcomes including complete resection, postoperative complications and recurrent rate were analyzed.?Results?54 patients (96.4 %) were successfully treated with ESD, while the other 2 patients (3.6 %) suffered severe complications (hemorrhage or perforation). Postoperative pathologic and immunohistochemical results showed that CD117 in 51 cases was positive (91.1 %), CD34 in 47 cases was positive (83.9 %). No recurrence was detected between 3-month and 48-month follow-up period.?Conclusion?This study showed that ESD was a safe and effective treatment for gastric stromal tumors.