Abstract: Objective To discuss the safety and superiority of the enhanced recovery after surgery (ERAS) in patients with Robot-Assisted Radical Prostatectomy (RARP). Methods A retrospective analysis of consecutive 490 patients from September 2014 to March 2018 underwent RARP, 230 patients were treated with ERAS as ERAS group, 260 patients were treated with traditional treatment as control group. All the data were calculated by using SPSS 20.0 software. Results Blood loss, transfusion rates, incidence of reoperation, incidence of intestinal adhesion, incidence of intestinal obstruction, pneumonia, pulmonary embolism, deep venous thrombosis, 30-Day Readmissions did not differ with ERAS use (all P > 0.05). The NRS pain score (P < 0.05) was lower in ERAS group; The first anal exhaust time (P < 0.05), the first defecation time (P < 0.05) and length of stay (P < 0.05) was shorter with ERAS than those without. Conclusions The use of ERAS pathways was safe and practicable for patients undergoing RARP. Recovery after RARP surgery can be improved by using enhanced recovery pathways. This adoption should be encouraged.