To explore the selection and treatment experience of laparoscopic repair for gastroduodenal ulcer perforation. Methods The clinical data and operation conditions of 60 cases of laparoscopic gastroduodenal perforation from May 2014 to May 2018 were retrospectively analyzed. According to the repair methods, the 8 suture group (5 cases), the interrupted suture group (34 cases), and the continuous suture group (21 cases) were observed, and the average perforation size (mm), repair time (min), bleeding volume (ml), slight complications (abdominal distention, fever, diarrhea, vomiting) and frequency of black stool were compared in each group. Results The suture time and the amount of bleeding in the 8 suture group were less than the latter two groups, but it was only suitable for ≤5.0 mm perforation; the average suture time of the reverse hand continuous suture group was 14.27 min and the bleeding volume of 12.34 ml in the suture process were significantly less than that in the intermittent suture group (32.34 min, 30.25 ml), and the difference was statistically significant (P < 0.05). There was no significant difference in frequency of slight complications and frequency of black stool (P > 0.05). Conclusion Laparoscopic surgery has advantages of less trauma and fewer complications in treatment of perforation of gastroduodenal ulcer. The 8 stitch method is recommended for the perforation of ≤5.0 mm, which is simple and rapid. For 5.0 mm perforation, continuous stitching is efficient and reliable.