To study the clinical effect of hysteroscopic electric resection combined with uterine artery embolization in treatment of postpartum refractory residual placenta. Methods 50 cases of postpartum refractory residual placenta from August 2017 to August 2018 were selected. The random number method was divided into observation group (25 cases) and control group (25 cases). The control group was treated with traditional curettage after mifepristone orally and the observation group was treated with hysteroscopic electric resection after uterine artery embolization. The therapeutic effects of the two groups were compared and analyzed. Results The separately amount of bleeding during operation of the observation group and the control group was (12.52 ± 3.49) ml, (38.00 ± 6.12) ml, the operation time of the observation group and the control group was (21.00 ± 5.31) min, (35.40 ± 6.52) min respectively, the success rate of operation of the observation group and the control group was 96.0% (24/25), 56.0% (14/25) respectively, the time of vaginal bleeding after operation of the observation group and the control group was (6.88 ± 2.11) d, (10.56 ± 2.26) d respectively, and the menstrual recovery time after operation of the observation group and the control group was (30.20 ± 2.84) d, (40.32 ± 4.48) d respectively. All the differences were statistically significant (P < 0.05). Conclusion Hysteroscopic electric resection combined with uterine artery embolization for postpartum refractory residual placenta has the advantages of less bleeding, high success rate of operation and good recovery after operation, it provides a new idea for clinical treatment of refractory residual placenta and opens up a new horizon.