Objective To evaluate the safety and effectiveness of the modified HoLEP operation in treatment of benign prostatic hyperplasia with 360°pre-cuturethral mucosal.Methods Clinical data of 89 patients with benign prostatic hyperplasia underwent the modified HoLEP operation in treatment of benign prostatic hyperplasia with 360°pre-cuturethral mucosal from June 2018 to February 2020 was retrospectively analyzed. The clinical data of patients was recorded, then analyze and evaluate the efficacy and safety of the modified HoLEP.Results All the 89 cases were successfully operated. The operation time was 45～170 minutes and the mass of the removed glands was 30～180 g. The catheter was left for 3～6 days, with an average of (3.5 ± 1.5) days. The postoperative hemoglobin concentration was (125.3 ± 21.5) g/L. Three months after the operation, the IPSS was (8.2 ± 2.2), the maximum urine flow rate was (22.9 ± 5.1) mL/s, and the remaining urine volume was (36.7 ± 12.8) mL. 78 cases after the modified operation can achieve immediate urinary control, and 7 cases can also achieve urinary control within 48 hours and do not need diapers in daily life. 2 cases (2.2%) had transient stress urinary incontinence for 3 months; 1 case (1.1%) had transient stress urinary incontinence 4 months after catheter removal, 1 case (1.1%) had transient stress urinary incontinence 8 months after catheter removal. There was no permanent urinary incontinence after the operation. During the 3-month follow-up, 1 case of external urethral stenosis and 1 case of bladder neck contracture were treated surgically.Conclusion The modified HoLEP operation for the treatment of benign prostatic hyperplasia with 360°pre-cut urethral mucosa is safe and effective, and the incidence of postoperative urinary incontinence is low, which is worthy of promotion.