Objective To investigate the efficacy and safety of laparoscopic-assisted radical gastrectomy for distal gastric cancer in advanced gastric cancer.Methods 70 patients with advanced gastric cancer from June 2017 to June 2019 were selected as the research objects, and they were randomly divided into the control group (n = 35) and the observation group (n = 35); The control group were given radical laparotomy for radical gastric cancer, and the observation group were given laparoscopic-assisted radical gastrectomy for distal gastric cancer. The surgical indicators, postoperative recovery, serum inflammatory factor levels, postoperative complications, and survival rate were compared between the two groups.Results The incision length was (5.7 ± 0.8) cm in the observation group, which was significantly shorter than that of the control group (20.6 ± 1.9) cm; The intraoperative blood loss was (185.2 ± 68.6) mL in the observation group, which was significantly less than that of the control group (387.4 ± 120.5) mL (P < 0.05); The operation time was (275.3 ± 42.6) min in the observation group, which was significantly longer than that of the control group (201.5 ± 29.8) min (P < 0.05); The number of lymph node dissections in the observation group was (23.6 ± 5.8), compared with (24.2 ± 6.1) in the control group, and there was no significant difference (P > 0.05). The getting out of bed time, postoperative exhaust time and hospital stay in the observation group were (2.9 ± 0.9) d, (4.1 ± 0.7) d and (13.1 ± 2.8) d, which were significantly shorter than those in the control group (4.8 ± 1.2) d, (5.2 ± 1.1) d, (20.2 ± 4.3) d (P < 0.05). 3 days after operation, the C-reactive protein (CPR) and interleukin-6 (IL-6) of observation group were (18.3 ± 1.4) mg/L and (92.4 ± 15.3) μg/L, which were significantly lower than those of control group (29.1 ± 2.4) mg/L and (118.3 ± 14.4) μg/L (P < 0.05). The incidence of complications in the observation group (5.7%) was significantly lower than that in the control group (22.9%) (P < 0.05). The 1-year and 2-year survival rates in the observation group were 85.8% and 60.0%, respectively, and there was no significant difference compared with 85.8% and 57.1% in the control group (P > 0.05).Conclusion Laparoscopic-assisted radical gastrectomy for distal gastric cancer has less injury, less bleeding, and better lymph node dissection. The patient has a faster postoperative recovery, a lower level of inflammatory factors, and a lower incidence of complications. And the postoperative survival rate of the patients was not significantly different from that of the open surgery, it is worthy of popularization and application in clinic.