Objective To analyze the clinical value of applying laparoscopic duct lithotomy in patients with complicated intrahepatic bile duct stones.Methods 106 patients with complicated intrahepatic bile duct stones were selected from February 2018 to February 2020. Patients were randomized into routine groups (n = 53, underwent traditional laparotomy), and treatment groups (n = 53, underwent laparoscopic bile duct lithotomy). The surgical effect, levels of inflammatory factors, complication incidence, recurrence rates of disease stones, and quality of life scores were compared between the two groups.Results The anal recovery and exhaust time, hospital stay and operation time in the treatment group were significantly shorter than those in routine group, and the amount of intraoperative bleeding was significantly less than that in routine group (P < 0.05). Three days after operation, the levels of C reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1 (IL-1) in treatment group were significantly lower than those in routine group (P < 0.05), the complication rate and stone recurrence were lower than those in routine group (P < 0.05), and the quality of life score was higher than that in routine group (P < 0.05).Conclusion Laparoscopic bile duct lithotomy in patients with complicated intrahepatic bile duct stones not only increases the treatment effect, reduces the recurrence of the disease, but also facilitates the removal of inflammatory factors and promotes the body recovery.