Objective To establish and validate a nomogram model for predicting the progression risk of patients with gastric low-grade intraepithelial neoplasia (LGIN) after the eradication of Helicobacter pylori (HP).Methods Patients who were diagnosed as gastric LGIN by gastroscopic biopsy were collected, followed up for 2 years, with HP eradicated. Independent risk factors screened for significant differences by univariate and multivariate analysis, and establish a gastric LGIN pathological upgrade nomogram model, then use C index, ROC curve, correction plan to verify the stability and reliability of the nomogram.Results 153 of whom were pathological upgrade. Univariate analysis showed that there were statistically significant differences between the two groups in gender, lesion diameter, boundary, number, shape and erosion. Multivariate analysis showed that male patients, lesion diameter ≥ 1 cm, bordered, depressed and non-erosion were independent risk factors for pathological progression. Then the predictive nomogram was established, and the stability of the model was verified by the C index of 0.775 (0.724 ~ 0.826), the AUC of 0.740 and the smart calibration curve.Conclusion This model has good reliability and can be used to evaluate the risk of pathological progression after the eradication of HP in gastric LGIN patients, and guide the selection of treatment modalities.