Objective To compare the safety, efficacy and clinical operability of microenteral nutrient tubes in two endoscopic gastrostomy.Methods 37 patients with swallowing dysfunction from January 2020 to August 2021 were selected and randomly divided into group A and group B according to the random number table method. In both groups used endoscopic-assisted lien and endoscopic tubular callback, respectively.Results The success rate in two groups were 100.00%, and the incidence of complications were 0.00%; The operation time in group B was significant shorter than that in group A, the difference was statistically significant (P < 0.05); The tube shift rates under C-arm fluoroscopy perspective after one week in group B was lower than that in group A, the difference was statistically significant (P < 0.01).Conclusion Endoscopic-assisted lien and endoscopic tubular callback can be successfully placed in endoscopic gastrostomy intestinal nutrition tube, but endoscopic tubular callback has more advantages in terms of operation time and tube displacement rate after one week.