Objective To compare the efficacy of endoscopic submucosal dissection (ESD) using the flexible auxiliary single-arm transluminal endoscopic robot (FASTER) with that of the traditional technique, and explore a safer and more efficient ESD operation method.Methods FASTER-assisted ESD and traditional ESD were used to operate in the isolated pig esophagus model. The differences of total procedure time, ESD time, the rate of direct-vision dissection,complete en bloc resection and complication rate between the two groups were compared and analyzed.Results The total procedure time [(19.2 ± 2.9) and (28.9 ± 8.2) min] and ESD time [(13.0 ± 2.9) and (21.6 ± 8.3) min] were significantly shorter in FASTER-assisted ESD group than those in traditional ESD group, the differences were statistically significant (P < 0.01); The rate of direct-vision dissection was significantly higher than that of the traditional ESD (96.2% and 65.4%), the difference was statistically significant (P = 0.014). Muscle layer injury rate was significantly lower than of the traditional group (19.2% and 69.2%), the difference was statistically significant (P < 0.01). There was no significant difference in complete en bloc resection rate and perforation rate between the two groups (P > 0.05). These advantages were more apparent in esophageal non-gravity lesions.Conclusion Esophageal ESD assisted by FASTER is safer and more efficient than traditional ESD.