Objectives To investigate the clinical efficacy on combined application of ear canal injected administration dispenser and triamcinolone acetonide econazole nitrate cream in the treatment of mycosis externa.Methods Clinical data of 130 patients (166 ears) diagnosed with mycosis externa from January 2023 to December 2023 were collected and randomly divided into two groups. In the observation group, 65 cases (86 ears) were treated with ear canal injected administration dispenser combined with triamcinolone acetonide econazole nitrate cream, while in the control group, 65 cases (80 ears) applied clean cotton swabs with triamcinolone acetonide econazole nitrate cream to the external auditory canal by themselves to treat mycosis externa. All the patients were treated for 4 weeks and followed up for half a year. The clinical efficacy, recurrence rate and adverse reactions were statistically analyzed and compared.Results The total effective rate of the observation group was 97.67%, which was significantly higher than that of the control group was 73.75%, there was a significant difference between the two groups (P < 0.05). There were no obvious adverse reactions in either group. No obvious recurrence was observed in the recovered patients of both groups during the follow-up period.Conclusion The efficacy of combined of ear canal injected administration dispenser and triamcinolone acetonide econazole nitrate cream in the treatment of mycosis externa is significant. Compared with the traditional way of medicine application, the adverse reactions are less. It can improve the cure rate and reduce the recurrence rate, which is worthy in clinical application.