耳道推注式给药器联合使用曲安奈德益康唑乳膏治疗外耳道真菌病的疗效观察
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南京大学医学院附属鼓楼医院(南京鼓楼医院)耳鼻咽喉头颈外科,江苏 南京 210008

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通讯作者:

林川耀,E-mail:lcyent@163.com

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国家自然科学基金重大项目(No:82192862);江苏省重点研发计划(No:BE2023653);江苏省医学重点学科/实验室(No:ZDXK202243)


Curative effect observation on combined application of ear canal injected administration dispenser and triamcinolone acetonide econazole nitrate cream in the treatment of mycosis externa
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Department of Otolaryngology Head and Neck Surgery, the Affiliated Hospital of Nanjing University Medical School (Nanjing Drum Tower Hospital), Nanjing, Jiangsu 210008, China

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    摘要:

    目的 探讨耳道推注式给药器联合使用曲安奈德益康唑乳膏治疗外耳道真菌病的临床疗效。方法 收集2023年1月-2023年12月于该院耳鼻咽喉头颈外科就医,诊断为外耳道真菌病的患者130例(166耳),随机分为观察组65例(86耳,采用耳内镜下耳道推注式给药器联合使用曲安奈德益康唑乳膏治疗)和对照组65例(80耳,采用沾有相同乳膏的清洁棉签,患者自行涂抹外耳道治疗)。所有患者均治疗4周,并随访半年,比较两组患者临床疗效、复发率和不良反应等指标。结果 观察组总有效率为97.67%,明显高于对照组的73.75%,差异有统计学意义(P < 0.05)。两组患者治疗过程中均未出现明显的不良反应。随访期间,两组患者均未见明显复发。结论 耳道推注式给药器联合使用曲安奈德益康唑乳膏治疗外耳道真菌病的疗效好,相比较传统方式涂药,其具有不良反应小、治愈率高和复发率低等优势,值得临床推广应用。

    Abstract:

    Objectives To investigate the clinical efficacy on combined application of ear canal injected administration dispenser and triamcinolone acetonide econazole nitrate cream in the treatment of mycosis externa.Methods Clinical data of 130 patients (166 ears) diagnosed with mycosis externa from January 2023 to December 2023 were collected and randomly divided into two groups. In the observation group, 65 cases (86 ears) were treated with ear canal injected administration dispenser combined with triamcinolone acetonide econazole nitrate cream, while in the control group, 65 cases (80 ears) applied clean cotton swabs with triamcinolone acetonide econazole nitrate cream to the external auditory canal by themselves to treat mycosis externa. All the patients were treated for 4 weeks and followed up for half a year. The clinical efficacy, recurrence rate and adverse reactions were statistically analyzed and compared.Results The total effective rate of the observation group was 97.67%, which was significantly higher than that of the control group was 73.75%, there was a significant difference between the two groups (P < 0.05). There were no obvious adverse reactions in either group. No obvious recurrence was observed in the recovered patients of both groups during the follow-up period.Conclusion The efficacy of combined of ear canal injected administration dispenser and triamcinolone acetonide econazole nitrate cream in the treatment of mycosis externa is significant. Compared with the traditional way of medicine application, the adverse reactions are less. It can improve the cure rate and reduce the recurrence rate, which is worthy in clinical application.

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张思思,周宇,许应鹏,林川耀,高下.耳道推注式给药器联合使用曲安奈德益康唑乳膏治疗外耳道真菌病的疗效观察[J].中国内镜杂志,2025,31(5):1-7

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  • 收稿日期:2024-10-14
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  • 在线发布日期: 2025-06-11
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