Objective: In order to prevent and reduce bleeding of exthpate polypus of alimentary canal, we try to adopt a new method. Methods: Single nylon snares` ligation or high frequency electrocoagulation after nylon snares` ligation with endoscopy was treated with polypus of alimentary canal. Results: In the group of treated (36 polypus` diameters more than 2 cm in 33 cases), the rate of cure is 97.3% and the rate of bleeding is 2.7%. In the group of comparison (52 polypus in 48 cases), the rate of cure is 88.9% and the rate of bleeding is 11.1%. Conclusions: In order to prevent and reduce bleeding of extirpate polypus, it is the effective method that nylon snares` ligation treated with subpedicel or thick pedicel polypus which diameters are more than 2 cm.