【Objective】 To detect the merits or shortage of suprapubic sonographically guided trancervical radio frequency ablation and laparoscope guided radio frequency ablation on hysteromyoma. 【Methods】 135 women bearing symptomatic intramural uterine myomas. 86 cases were under process of transcervical radio frequency thermal ablation with suprapubic sonographic guidance (SSG group). The others, 49 women were performed the laparoscope guided radio frequency ablation (TG group). Measurement of reduction in the volumes of myomas was scheduled at 6 months after operation. The pain after operation was soon evaluated by a rating scales "Changhai pain rules". The curative effect and complication were observed. 【Results】 6 months after radio frequency ablation, the total effective rate was 91.9%, 95.9% respectively, SSG group showed slight post operational pain with significant deviation. While TG group's cure rate was more excellent than SSG group, on the ablation of patient with multiple hystermyoma or tumor huger than 4 cm in diameter. 【Conclusion】 Both of the two manners show the merits of effective, micro-traumatic, shot time in ward and safe, especially the SSG. While to the patient with multiple hystermyoma or tumor huger than 4 cm in diameter, laparoscope guided radio frequency ablation will be judicious.